A new refrigerator-sized factory can rapidly pump out a diverse assortment of drugs on demand.

Researchers designed the system to offer a speedy alternative to large-scale pharmaceutical production. Rejiggering chemical inputs and the device’s collection of tanks and tubes allowed the team to produce four different drugs: an anesthetic (lidocaine), an antihistamine (Benadryl), an anti-anxiety medication (Valium) and an antidepressant (Prozac). The self-contained system was equipped to mix, heat, pump and purify ingredients into hundreds to thousands of doses of pharmaceutical-grade compounds. Making each medication took the device between roughly 12 and 50 hours, the team reports in the April 1 Science. Attached computers allow one person to control and monitor the whole process.

For now, the device only makes liquid medications. But it may be a step toward overcoming limitations of cumbersome drug-making supply chains by developing automated tools that make medications on demand.

Over the years, readers have on occasion written to me to point out what they see as an increasing politicization of Science News. These are not accolades — more than one of those readers has contemplated ending their subscription. Some of those critics deny climate change, some oppose GMOs, others view any policy discussion in our coverage as worrisome. So, are we actually getting involved in politics?
My short answer is no. But there are many areas in which science has important things to say to citizens and policy makers. And reporting on the body of evidence that relates to societal issues falls fully within our mission, even for scientific questions with political ramifications. It’s well worth the ink to inform people about pressing problems or provide factual information in what have become hotly contested and polarizing debates.
Science can help establish what’s known, what’s not known and how scientists might find answers. That’s what Science News reports on, with the aim of giving readers not a political argument but a clear idea of where the evidence currently stands and what questions remain. Facts based on sound science can perhaps even provide a common ground for people of differing opinions to speak to each other rationally.

In the case of what researchers can say with respect to the efficacy of gun laws, it turns out that there are more questions than answers. The numbers on U.S. gun violence are clear: In 2013, the United States had many more gun-related deaths than other nations with similar standards of living. But as Meghan Rosen investigated the state of the knowledge, it became evident that now, in the United States, it’s hard to even do the science. Researchers told her that they just don’t have the data needed to answer questions about the impacts of different gun control laws.

“I thought the evidence behind well-known gun control policies would be more clear-cut,” Rosen says. But studies of background checks, waiting periods and a 1994 assault weapons ban don’t necessarily show a corresponding reduction in gun violence. Maybe such laws don’t do what lawmakers intended, but there are also confounding factors that may dilute any conclusions, Rosen reports. The 1994 ban on assault weapons, for example, stopped only sales of new weapons and didn’t apply to those already in circulation. Most disturbing to Rosen was the blocking of scientific research by Congress, which has maneuvered to stop the Centers for Disease Control and Prevention and the National Institutes of Health from doing or funding work that might advocate or promote gun control laws. That has effectively reduced research into the best ways to prevent gun violence.

The science that has been done on whether U.S. gun control laws reduce gun violence has been mixed. There aren’t a lot of straightforward answers to guide policy. But in this case, science has not had a fair chance to build the foundation for an evidence-based conversation. Without facts, it really is all political. Our aim is to find and report on those facts (or the lack of them), so that they can become part of the conversation.

A gut microbe collected from chinchilla droppings might be the first complex life form to lack even a shred of a supposedly universal organelle.

Monocercomonoides, a one-celled gut microbe collected from a pet chinchilla in Prague decades ago, apparently has no mitochondria, the organelles known as the cell’s power plants. Cataloging DNA in the microbe turns up none of the known genes for mitochondrial proteins. But stealing genetic material from bacteria — which survive without mitochondria — allowed the microbe to do without them, too, researchers report May 12 in Current Biology.
Mitochondria are tiny capsules that speckle the insides of all complex cells from pond scum to people, or so textbooks have said for decades. Some complex (or eukaryotic) cells look as if they have no mitochondria; so far, though, further searches have eventually detected mitochondrial remnants.

But Monocercomonoides appears to have completely done away with mitochondria and the genes to make them, says study coauthor Anna Karnkowska, an evolutionary biologist now at the University of British Columbia in Vancouver.

This discovery marks “the most extreme mitochondrial reduction observed,” says Vladimír Hampl of Charles University in Prague, also a coauthor of the study.

The new work also supports the idea that there really is no single core function that defines mitochondria. Although commonly described as cell powerhouses, mitochondria don’t have much to do with supplying energy for cells that live in low-oxygen or no-oxygen environments, Karnkowska says. For these anaerobic cells, mitochondria can serve as more of a building studio. One supposedly essential mitochondrial function, scientists have proposed, is assembling clusters of iron and sulfur that activate a class of widely useful cell compounds.

Bacteria and other simple (prokaryotic) cells have their own assembly systems, and they don’t need to wall off the construction of iron-sulfur clusters. The newly studied Monocercomonoides carry the genes for an assembly system that looks as if it was taken from bacteria, the researchers conclude.
Researchers discovered the lack of mitochondrial genes and the bacterial substitute while working out the DNA components that encode instructions for all the proteins in the whole organism. There were notably no signs of chaperone proteins for conveying other proteins through membranes, something mitochondria do. Nor did other signature mitochondrial proteins show up.

“Pretty amazing story,” says Roland Lill of Philipps University of Marburg in Germany, who studies the way cells use iron. The new paper doesn’t change the basic idea that complex cells need very special conditions, usually created only inside mitochondria, to build their iron-sulfur clusters. “But the beauty of biology,” he says, “is that there are always amazing exceptions to basic biological rules.”

Laser blasts might help scientists tweak Earth’s thermostat by shattering the ice crystals found in cirrus clouds.

Zapping tiny ice particles in the lab forms new, smaller bits of ice, researchers report May 20 in Science Advances. Since clouds with more numerous, smaller ice particles reflect more light, the technique could combat global warming by causing the clouds to reflect more sunlight back into space, the scientists say.

Scientists from the University of Geneva and from Karlsruhe Institute of Technology in Germany injected water drops into a chilled chamber that mimics the frigid conditions high in the atmosphere, where wispy cirrus clouds live. The water froze into spherical ice particles, which the scientists walloped with short, intense bursts of laser light.
When the laser hits an ice particle, ultrahot plasma forms at its center, producing a shock wave that breaks the particle apart and vaporizes much of the ice. The excess water vapor left in the aftermath then condenses and freezes into new, smaller ice particles.
Applying this technique to clouds is “a long, long, long way in the future,” says physicist Mary Matthews of the University of Geneva, a coauthor of the study. Current laser technology is not up to the task of cloud zapping — yet. “What we are hoping for is that the advances in laser technology, which are moving faster and faster all the time, will enable high-powered, mobile lasers,” Matthews says.

But tinkering with cirrus clouds could backfire if scientists aren’t careful, says atmospheric scientist Trude Storelvmo of Yale University. The clouds also trap heat, through the greenhouse effect, so breaking up their ice particles could actually warm the Earth. The method“could potentially work, but only if you target certain types of cirrus clouds,” she says, such as those that are very thick.

There could also be warming if fossil fuels are burned to power the laser, says David Mitchell of the Desert Research Institute in Reno, Nev. “I think it’s really interesting research, but I’m just not seeing how it’s going to make the world a cooler place.”

U.S. 191 is one of the driving options for people headed to Grand Teton or Yellowstone National Parks. But the road also cuts through prime territory for mule deer and pronghorns. And cars and large wildlife don’t usually mix well. When they do tangle, the cars end up heavily damaged, and the animals end up dead.

In an effort to reduce this conflict, the Wyoming Department of Transportation spent nearly $10 million to install two overpasses and six underpasses, along with deer-proof fencing, on sections of the highway near Daniel Junction in 2012. The sites for the passes were chosen based, in part, on the migration patterns of mule deer and pronghorns through the area.

Shortly after the installation, the animals were seen using the crossings, and vehicle collisions appeared to decline. The project was labeled a success. Now, an analysis of the project finds just how successful it has been: Car collisions with pronghorn have disappeared entirely and those with mule deer have dropped by 79 percent, Hall Sawyer of Western Ecosystems Technology Inc., and colleagues report May 16 in the Wildlife Society Bulletin.

Two digital cameras were installed at each overpass and one at each underpass to monitor wildlife using the crossings during the spring and fall migration periods in 2012 through 2015. Thousands of animals started using the pathways, and each year, more and more animals crossed the highway using these safe paths. Over the years, 40,251 mule deer and 19,290 pronghorn made their way through the passages.

Of the mule deer passing through, 79 percent used the underpasses. But among pronghorns, 92 percent took the overpasses. This confirms something that researchers had thought would be true but never really had any data to back up. They figured that ungulates such as pronghorns that live in open areas and are heavily reliant on vision to detect predators should prefer overpasses, because the structures would allow the animals to have better vision and movement. The new finding supports this, at least for pronghorns, and shows that building overpasses, which are more expensive than paths beneath highways, really is necessary for some animals.

This area of U.S. 191 was one of the worst for wildlife vehicle collisions before the crossings were built, averaging 85 per year from 2005 to 2012. By the third year after the installation, though, collisions had dropped to just 16 per year.

When the crossings were put in place, the Department of Transportation claimed that, by preventing vehicle collisions, the project would essentially pay for itself in 20 years. But this project has been so successful, the team calculates, that a crossing could pay for itself in just 4 years. And then, of course, there’s the benefit for the wildlife itself, which can now more easily and safely move through the landscape.
The team does note that Wyoming did have to make a few adjustments to the project to accommodate human behavior. The overpasses are edged with high berms to prevent animals from seeing the highway, but those berms proved tempting to ATV users and motorcyclists. Because this activity is damaging to vegetation and could reduce effectiveness of the crossings, the Bureau of Land Management had to post signs warning people away.

And when the crossings first went up, some canny hunters figured that the overpasses were good spots to find hundreds of pronghorn; hunting is now banned within 800 meters of a wildlife overpass.

Scientists have found a new way to study how cancer cells divide and thrive in difficult-to-reach crannies of the body.

Transparent artificial membranes — just nanometers thick — can be rolled into tubes to mimic capillaries that host spreading cancer cells, researchers report in the June ACS Nano. Cells squished inside such tubes didn’t organize their internal components the way they normally do before splitting. As a result, the cells divided unevenly, potentially introducing new mutations.
Inside the body, cancer cells fight for space. Sometimes they’ll spread, or metastasize, to other organs via tight blood vessels. Although cancer cells are more likely to kill once they spread, scientists still don’t understand how the abnormal cells divide inside such tiny tubes. These cells are difficult to study in the body because they’re tucked away in hard-to-reach places. They’re challenging to study in the lab, too, because they behave differently in a petri dish than in their natural environment.

By replicating that environment more closely, this experiment gives “an appreciation for what it’s like to be a cell in a body,” says Buzz Baum, a biologist at University College London who was not involved in the work.

Other researchers have looked at cells constrained in other ways. But the nanotubes are round, just like blood vessels. They’re transparent, making it easier to visualize what’s happening inside. And it’s possible to study many cells at once by growing nearly a thousand tubes, all exactly the same size, on a chip slightly larger than a postage stamp.

When watching single human cancer cells inside the tubes through high-powered microscopes, the team noticed that the squished cells didn’t divide symmetrically. Instead of sending half the chromosomes to each new cell, some of those cells got extra genetic instructions, while others were shortchanged.

The squished cells also took longer to divide. And the protein structures that help guide the chromosomes and organelles into place before division didn’t develop correctly, says study coauthor Wang Xi, a materials scientist who did the work at the Leibniz Institute for Solid State and Materials Research Dresden in Germany.
Cancer cells succeed by mutating enough that they can evade capture, without becoming too mutated to keep replicating.

“A cell that makes too many mistakes will just die,” says Baum.

When cells are trapped inside blood vessels, “they become misshapen but they’re still able to divide,” says Xi, now at the National University of Singapore.

Xi and his colleagues think that a bulging of the cell membrane in response to pressure, called blebbing, might help the trapped cells divide in a slightly less distorted way. When the researchers prevented the cells from blebbing, the division was even more uneven. But because the team can’t yet explain why this would be the case, it’s too soon to say whether blebbing itself is responsible for the improved division.

Baum says he has shown similar deformities in cancer cells dividing under other types of constraints. But, he adds, it’s important to have systems that more closely replicate the body’s internal environment. Otherwise, it can be a big jump between doing tests in a petri dish and in a live animal.

Study coauthor Christine Schmidt, a biochemist at the University of Cambridge, says understanding how cancer cells manage to divide in tight quarters could eventually inspire ways to kill spreading cancer cells without hurting healthy cells.

Knuckleballs baffle baseball players with their unpredictable swerves. A new study suggests a possible cause of the pitch’s erratic flight — sudden changes in the drag force on a ball, due to a phenomenon called a drag crisis.

The result is at odds with previous research that attributed the zigzags to the effect of airflow over the baseball’s seams. Scientists report the finding July 13 in the New Journal of Physics.

Knuckleballs are well known in baseball, but similar phenomena also confound players in soccer and volleyball. Knuckleballs occur when balls sail through the air with very little spin, producing unstable flight.
In drag crisis, the thin layer of air surrounding the ball flips between turbulent and smooth flow, abruptly changing the drag forces on the ball. If the transition occurs asymmetrically, it can push the ball to one side. “This phenomenon is intermittent” and hard to predict, says study coauthor Caroline Cohen, a physicist at École Polytechnique in Palaiseau, France. “We can’t know in advance [to] which side it will go.” Balls must move at a certain speed to experience a drag crisis, which may be why knuckleballs tend to be thrown slower than other pitches, the researchers suggest. While the fastest pitches can top 100 miles per hour, knuckleballs are usually closer to 60 or 70 miles per hour.

The scientists built a knuckleball machine, designed to launch a beach ball without any spin, and measured how much the ball veered off course. Then they calculated the ball’s expected motion based on the physics of the drag crisis and found that the predicted trajectories matched the experiments. The scientists’ calculations also correctly predict knuckleball-like phenomena in soccer, volleyball, cricket and baseball — but not in sports like tennis or basketball, where knuckleballs aren’t seen due to the properties of the ball, including texture, typical speed and how far it flies.

“It’s a fine piece of work,” says Alan Nathan of the University of Illinois at Urbana-Champaign, who studies the physics of baseball (SN: 3/23/13, p.32). But he is not entirely convinced by the explanation of knuckleballs. “Wind tunnel experiments seem to strongly suggest that it’s associated with the seams on the ball,” Nathan says, which can create turbulence that causes the ball to swerve.

So knuckleballs may remain as much of a challenge to explain as it is to hit them.

A roughly 27-million-year-old fossilized skull echoes growing evidence that ancient whales could navigate using high-frequency sound.

Discovered over a decade ago in a drainage ditch by an amateur fossil hunter on the South Carolina coast, the skull belongs to an early toothed whale. The fossil is so well-preserved that it includes rare inner ear bones similar to those found in modern whales and dolphins. Inspired by the Latin for “echo hunter,” scientists have now named the ancient whale Echovenator sandersi.
“It suggests that the earliest toothed whales could hear high-frequency sounds,” which is essential for echolocation, says Morgan Churchill, an anatomist at the New York Institute of Technology in Old Westbury. Churchill and his colleagues describe the specimen online August 4 in Current Biology.

Modern whales are divided on the sound spectrum. Toothed whales, such as orcas and porpoises, use high-frequency clicking sounds to sense predators and prey.

Filter-feeding baleen whales, on the other hand, use low-frequency sound for long-distance communication. Around 35 million years ago, the two groups split, and E. sandersi emerged soon after.

CT scans show that E. sandersi had a few features indicative of ultrasonic hearing in modern whales and dolphins. Most importantly, it had a spiraling inner ear bone with wide curves and a long bony support structure, both of which allow a greater sensitivity to higher-frequency sound. A small nerve canal probably transmitted sound signals to the brain.
“Scientists have long suspected that early toothed whales could produce the high-frequency sounds needed for echolocation based on features on their skulls,” says Travis Park of Monash University in Melbourne, Australia. Previous work points to early toothed whales sensing those high frequencies. Park and his colleagues reported in April in Biology Letters the discovery of a 26-million-year-old lone ear bone showing signs of high-frequency hearing. But it wasn’t connected to a skull and, thus, couldn’t be tied to a specific whale species.

Tracing inner ear features in CT scans of 24 ancient and modern whales, including E. sandersi, plus two hippos, whales’ closest living relatives, Churchill’s team ups the ante. Because primitive versions of the bony spiral and nerve canal appeared before the first known toothed whale, the researchers suggest that rudimentary high-frequency hearing might have emerged in the common ancestor of toothed and baleen whales at least 43 million years ago. If so, baleen whales lost their high-frequency hearing at some point. Determining whether that’s truly the case requires more analysis and a wider array of fossil data, says Park, who’s unconvinced.

But there is growing consensus that the first toothed whales could hear and produce sounds at high-frequency ranges. The skull of a 28-million-year-old toothed whale also suggests that such animals could make high-frequency calls (SN: 4/19/14, p. 6). “The next step is to look at when their brains got big enough to process echolocation signals,” says Nicholas Pyenson, a paleobiologist at the Smithsonian’s National Museum of Natural History who was not affiliated with the study. “This is great, but there’s more to be done.”

Capybaras, giant rodents native to South America, could become Florida’s next big invasive species, a biologist warned August 3 in Columbia, Mo., at the 53rd Annual Conference of the Animal Behavior Society.

“Capybaras have been introduced to northern Florida,” said Elizabeth Congdon of Bethune-Cookman University in Daytona Beach, Fla. And there are enough similarities to nutria — large invasive rodents that have caused havoc in many states — to warrant a closer look at the South American newcomers.

There are currently about 50 capybara loose in northern Florida. Now, that may not seem like an invasion, and it’s not — yet. But these animals are the world’s largest rodent, growing to 50 kilograms or more. In the wild, the semiaquatic animals live in social groups in forests where they can be near bodies of water, such as rivers, lakes or swamps. They are herbivores that can subsist on a wide variety of vegetation, from grass to tree bark. And they reproduce at a fair pace, producing an average of four, and up to eight, pups per litter.

Most people wouldn’t look at those characteristics and think “I want to own one of those animals,” but some have. Capybaras are one of the many exotic creatures that people have tried to turn into pets. (Owning one is legal in some states.) But the animals can get loose, or people may purposely release them when they no longer want to own a giant rodent.

A capybara (or 50) loose in the countryside or city is not automatically an invasive species. The difference between an invasive and a nonnative exotic is whether an organism is causing environmental or economic harm, or harm to human health.

Congdon and her undergraduate students have been studying the potential for capybaras to make that transition from exotic to invasive, and they have been looking for similarities to nutria. Those large rodents were first imported to the United States in the early 1900s; the animals were farmed for their fur in Louisiana. But they escaped — some were also purposely released as weed mitigators — and quickly established themselves in Louisiana’s many swamps. Efforts to control the animals, such as hunting, have largely failed.

Nutria, which are smaller than capybaras, reproduce at about the same rate as the giant rodents. But one of the things that have made nutria such a menace — their propensity to dig into riverbanks, levees and other places that can cause problems when the ground disintegrates — appears to be a trait they don’t share with capybaras.
While coyotes and dogs are know to hunt nutria, it appears that nothing in the United States, other than a human, is big enough to kill a capybara. No animals here are equivalent to the capybara’s natural South American predators, which include anacondas, puma and jaguar, Congdon noted.

The state of Florida says only that a breeding population of capybaras “may exist,” but Congdon is pretty sure that there is one. In 1995, five animals escaped from a wildlife facility near Gainesville, and they are probably at least part of the source of those 50 capybaras now living in Florida. “Several sightings suggest they have been breeding,” Congdon said, including the finding of a juvenile capybara. Given the similarities to the nutria, and the ability of capybaras to adapt to a variety of habitats, including cities, “they might be able to make a go of it in the United States,” Congdon concluded.

But Congdon isn’t advocating that wildlife managers kill all the capybaras in Florida. The animals represent “an opportunity to study the process of invasion,” she said. Plus, a population in Florida would be a lot easier for her to access than the one she studied in Venezuela as a gradate student. “We want to keep them from spreading,” she said, “but can we please not kill them all so I can study them?”

Ötzi had Copper Age style.

The 5,300-year-old Tyrolean Iceman, whose body was found poking out of a glacier in the Italian Alps in 1991, incorporated hides from at least five domesticated and wild animal species into his apparel, a new genetic study finds. Comparing mitochondrial DNA extracted from nine ancient leather fragments with DNA of living animals revealed the makeup of Ötzi’s clothes and a key accessory, says a team led by paleogeneticist Niall O’Sullivan. Mitochondrial DNA typically gets passed from mothers to their offspring.
Little is known about what people wore during Ötzi’s time. The findings provide a glimpse into how ancient European populations exploited domesticated animals to make clothes and other items.

Ötzi’s coat consisted of hides from at least three goats and one sheep, the scientists report August 18 in Scientific Reports. This garment may have been periodically patched with leather from whatever animals were available, the team suggests.

Goats also provided skin for the Iceman’s leggings, the new analysis indicates.

A sheepskin loincloth and a shoelace derived from European cattle round out Ötzi’s attire made from domesticated animals.

As for wild animals, Ötzi wore a brown-bear cap and toted a quiver made from roe deer. It’s impossible to know if the ancient man attached any special meaning to brown bears, “but he may have been an opportunistic hunter or a scavenger,” says O’Sullivan, of University College Dublin and EURAC Research in Bolzano, Italy.
A 2012 analysis of proteins from fur samples taken from Ötzi’s clothing identified sheep and a goatlike animal called a chamois as sources for the Iceman’s coat. A team led by biochemist Klaus Hollemeyer of Saarland University in Saarbrücken, Germany, also pegged goats and dogs or wolves as sources of skin for Ötzi’s leggings.

Disparities between Hollemeyer’s and O’Sullivan’s studies may stem from the two groups having sampled different parts of patchwork garments. In addition, the new report used advanced techniques for extracting and analyzing ancient DNA. That enabled O’Sullivan’s team to retrieve six complete mitochondrial genomes from Ötzi’s leather belongings.

O’Sullivan’s investigation “opens a new field of potential identification procedures for mammalian species in ancient leathers and furs,” Hollemeyer says.

A roughly 4,200-year-old legging found in the Swiss Alps in 2004 also features goat hide. Mitochondrial DNA extracted from that garment came from an ancient line of European goats that has largely been replaced by a genetically distinct goat population, a team led by archaeologist Angela Schlumbaum of the University of Basel in Switzerland reported in 2010.

The Swiss legging was found with pieces of bows and arrows, woolen clothes and many other artifacts where an ice patch in a mountain pass had partly melted. No human bodies have been found there.

“Possibly, goat leather was most comfortable” as legging material, says University of Bern archaeologist Albert Hafner, a coauthor of the Swiss legging study. “Modern leather trousers often use goat as well.”